Adobe and Microsoft have worked closely together to test Adobe Creative Cloud applications for reliability, performance, and user experience when installed on Intel-based systems running Windows 10. The latest versions of all Adobe Creative Cloud products are compatible.
Windows 10 includes a new web browser called Microsoft Edge, in addition to Internet Explorer 11. Currently, the Microsoft Edge browser does not support the Acrobat PDF plug-in. Internet Explorer 11, along with other major Windows browsers, continues to support the Acrobat PDF plug-in.
Additionally, see this knowledgebase article to resolve an MSVCR110.dll-related issue while using Creative Cloud apps on Windows 10.
Windows 10 is not a supported operating system for CS6 and earlier product versions. Limited testing with CS6 revealed no issues. Adobe recommends customers do their own testing on a non-production partition to ensure new OS'es work with their hardware, drivers, and workflows. Current support for CS6 is limited to up and running assistance (installation, deployment, downloading, and licensing) until discontinuation of support on May 31st, 2017. See Adobe Support Policy for full details.