When Reader or Acrobat is installed, it creates a Setup Files folder:
This folder is used as an installer cache containing the actual installer file. The installer file is used to repair the Reader or Acrobat installation. However, some companies keep the installer available on a network share, and therefore do not want the installer cache created, as it takes up space.
You can disable this folder during installation by using the Adobe Customization wizard to transform the standard MSI installer file. Disable the option "Enable Caching of installer files on local hard drive" under Installation Options.
To download and get more information on the Customization wizard, visit this link: