macOS Sierra 10.12.4 stops responding when you're using Illustrator CC 2017 or InDesign CC 2017 (April 2017 release) with the GPU enabled.
Install the most recent versions of Adobe Creative Cloud applications after upgrading to the latest version of macOS Sierra 10.12.5. For more information, see Get software updates for your mac.
To avoid this issue while you're working on macOS 10.12.4, disable the GPU from within the application.
Third-party plug-ins that are not compatible with Mavericks can cause Illustrator to crash at launch.
Illustrator CC 2014 (October 2014 release, version 2014.1) crashes when Extensis Suitcase Fusion 5 is installed.
Update the Extensis Suitcase Fusion 5 to most recent version.