You can print more than one page of a PDF onto a single sheet of paper. Printing multiple pages per sheet is also called N-up printing (such as 2-up or 6-up). You can specify how the pages are ordered, either horizontally across the page or in vertical columns.
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Also Applies to Reader

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Choose File > Print.
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From the Page Scaling pop-up menu, select Multiple Pages Per Sheet.
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From the Pages Per Sheet pop-up menu, select a value.
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From the Page Order pop-up menu, select Horizontal, Horizontal Reversed, Vertical, or Vertical Reversed:
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Click OK or Print.
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