Adobe has discovered the compatibility issues listed below with running Photoshop with macOS 10.12 (Sierra).

Adobe strongly recommends that customers update Photoshop 2017 prior to updating to macOS 10.12 (Sierra).

Older versions of Photoshop were not designed, nor extensively tested to run on macOS Sierra. We strongly recommend that customers do their own testing on a non-production partition to ensure that new operating systems work with their current hardware and drivers (printing, etc). You may wish to remain on an older version of the OS that is compatible with prior versions of our software.

If you do encounter issues not already documented, feel free to report them on our feedback site.

Adobe has discovered the compatibility issues listed below when running Photoshop CC 2015.5 and earlier on macOS 10.12 (Sierra).

Printing in macOS Sierra crashes while printing to some printers and devices

Photoshop would crash while printing on macOS Sierra 10.12.

Solutions: 

• Update to macOS 10.12.1
• Update to Photoshop CC 2017

For some printers, ensuring your printer driver is up-to-date will fix stability issues. Note: Just updating the driver may not work. You need to delete the driver, delete the printer, install the latest driver then install the printer. See this document from Apple on troubleshooting printing on OS X: Resolve Printer issues on your Mac.

The Cmd+Space keyboard shortcut in macOS Sierra launches both Siri and the Zoom In tool

Solution: Change the keyboard shortcut for Siri.

User Interface redraw issue when dragging the scroll bars in dialogs and panels

Solution: Update to Photoshop CC 2017

Workaround: For prior version of Photoshop, hover over the scrollable area and use the mousewheel or trackpad gesture to scroll the panel instead of clicking on the scroll bar and dragging it up and down.

Preview in browser doesn't work from Save For Web

Workaround: Save your images and/or HTML from Save for Web and open them from the Finder in the browser of your choice.

Our engineers are working on a complete solution for a future update of Photoshop CC.

Unexpected behavior while using Lasso tool or Polygonal Lasso tool

Workaround: Select Preferences > General. Deselect Show Messages.