Flash Builder Design mode is not supported in some of the combinations

Flash Builder displays a dialog saying "Design mode: Error during component layout. Choose Design>Refresh to refresh design mode".

Design mode is not supported in the following combinations:

• Flash Builder 4 and Flex 4.5.x SDK
• Flash Builder 4.5.x and Flex 4.0/4.1 SDK

You can find a JIRA related to this issue which is closed as Not a Bug.

https://bugs.adobe.com/jira/browse/FB-30942