Although you can install Lightroom on a case-sensitive partition, it cannot be run on such a partition. If it is on a case-sensitive partition, move the Adobe Photoshop Lightroom 4.app file to a partition that isn't case-sensitive.
Solution 3: Make sure that you have read and write permissions to the Flash Player folder and all its subfolders.
You need read and write permissions to the following folder: ~/Library/Preferences/Macromedia/Flash Player folder.
Important: Apple made the user library folder hidden by default with the release of Mac OS X 10.7. If you need access to files in the hidden library folder to perform Adobe-related troubleshooting, see How to access hidden user library files.
Change the permissions on this folder so that you have read and write permissions.
To change permissions on a file in Mac OS, do the following: