Adobe and Apple have worked closely together to test Adobe Creative Cloud applications and Adobe Creative Suite 6 applications for reliability, performance, and user experience when installed on Intel-based systems running Mac OS X Mavericks (v10.9). All Adobe CC and CS6 products are compatible, but a few products require updates to the latest builds to work properly. Adobe Photoshop CS5, CS4, and CS3 were also tested with Mac OS X Mavericks, and currently there are no known major issues.
As with any new release of an operating system, there could be unexpected issues that arise that were not discovered during testing. If you encounter any issues, report them using the bug reporting form.